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Plants with Opiate-Like Properties

Plants Containing Opiate Alkaloids

Disclaimer: This is meant for educational purposes only. Please do not seek out or use these compounds without consulting your physician.
Peripentadenia Mearsii
Peripentadenia Mearsii
Peripentonine A, B, and C, Peripentadenine and Mearsamine are alkaloids found in the leaves of this tree. Peripentadenine, Peripentonine A/B (isolated as inseparable diastereomers) and Perpentonine C showed IC50 values of 11.4, 69.2, and 30.9 microM for the delta-opioid receptor.
Nepeta Cataria
Catnip
This plant is called commonly known as catnip, catswort, and catmint. It Contains alpha, 7alpha, 7a alpha-nepetalactone. These all reduce pain.
Commiphora Myrrha
Myrrh
Contains furanoeudesma-1,3-diene which interact with the brain's opioid receptors.
Psychotria Colorata
Psychotria Colorata
Contains Psychotridine, an analgesic which also contains Hodgkinsine, a mu-opioid agonist.
Picralima Nitida
Akuamma
The seeds of this plants contain akuammidine, akuammine, akuammicine, akuammigine and pseudoakuammigine which interact with the mu-opioid receptors.
Psychotria Umbellata
This plant contains umbellatine, an opioid antagonist as well as Psychollatine, an indole with anxiolytic and antidepressant effects comparable to the potent tricyclic antidepressant imipramine.
Dalea purpurea
Contains the geranyl stilbenes Pawhuskin A, B and C. Pawhuskin A displayed the strongest opioid activity.
Nigella Sativa
Contains thymoquinone which acts on mu and kappa opioid receptors.
Stephania japonica
The hasubanan alkaloids interacts with the delta-opioid receptors and mu-opioid receptors.

Source Material

Analgesic properties of Umbellatine from Psychotria umbellate. Fernanda L, Victor AK, Amelia Thttp://informahealthcare.com/doi/abs/10.1076/phbi.40.5.336.8453
 
Psychopharmacological profile of the alkaloid psychollatine as a 5HT2A/C serotonin modulator. Meneghini L, Kerber V. Prod. 1995.
 
Antinociceptive profile of hodgkinsine. Amador TA, Verotta L, Nunes DS, 2000.
 
Involvement of NMDA receptors in the analgesic properties of psychotridine. Amador TA, Verotta L, Nunes DS, Elisabetsky E Phytomedicine : International Journal of Phytotherapy and Phytopharmacology 2001.
 
New geranyl stilbenes from Dalea purpurea with in vitro opioid receptor affinity. Belofsky G, French A, Wallace DR. Prod. 2004 PMID: 14738380
 
Alkaloids with human delta-opioid receptor binding affinity from the Australian rainforest tree Peripentadenia mearsii. Venables , Guymer G,, Forster PI, Carroll AR. J Nat Prod. 2007
 
Grandisines C-G, indolizidine alkaloids from the Australian rainforest tree Elaeocarpus grandis. Katavic PL, Venables DA. , Forster P, Guymer G. , Carroll A. Prod. 2006. PMID: 16989522
 
Opioid activity of alkaloids extracted from Picralima nitida. Menzies J, Paterson S, Duwiejua M, Corbett A. 1998.
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